S4572
Sigma
SANT-1
≥98% (HPLC), solid
| Synonym: | (4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine |
| CAS Number: | 304909-07-7 |
| Linear Formula: | C23H27N5 |
| Molecular Weight: | 373.49 |
| MDL number: | MFCD01827306 |
Description
| Packaging | air and nitrogen sensitive |
| Biochem/physiol Actions | SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist that directly inhibits by binding to the smoothened (Smo) receptor. SANT-1 inhibits wild type and oncogenic Smo with equal potency. |
Properties
| assay | ≥98% (HPLC) |
| form | solid |
| solubility | DMSO: >10 mg/mL |
| H2O: <2 mg/mL | |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
References
| reference | Chen, J.K., et al., Small molecule modulation of Smoothened activity. Proc. Natl. Acad. Sci. U. S. A. 99, 14071-14076, (2002) |
